How to Heal a Sprained Ankle Overnight: While it's not always possible to completely heal a sprained ankle overnight, there are a few things you can do to help speed up the healing process. Start by resting the ankle and elevating it above heart level to reduce swelling. Applying ice for 20 minutes at a time, every 2-3 hours, can also help to reduce inflammation. Compressing the ankle with a bandage can help to reduce swelling and provide support. Finally, make sure to keep weight off the ankle and avoid any activities that may aggravate the injury.